Naughty By Nature. de la Soul. Mobb Deep. LL Cool J. Justin Bieber. Moby.These artists - and countless others - have one thing in common: Melvin Bliss' "Synthetic Substitution." Released in 1973, Bliss' "Synthetic Substitution" started off as a throwaway B-side to his single "Reward." It would go on to become one of the most frequently sampled songs of the late 80s and early 90s, a legacy that continues to this day.